Planning permission has been granted for the Hillsborough Private Clinic on the Ballygowan Road, which it is understood will be operated by doctors from the area.
The clinic, which will be built on the site of an old farmhouse adjacent to the A1 dual carriageway, is expected to cost around £3 million to build.
The developers behind the scheme are hopeful that work will begin on the multi-million pound development by the summer.
The new state-of-the-art clinic will include operating theatres and overnight accommodation for patients.
There will also be facilities for research and development for contemporary medical techniques and aids.
Once operational, it is anticipated that the clinic will create and sustain a total of 120 direct and indirect jobs.
The planning application was submitted last year by Planning Development specialists Clyde Shanks and approval was granted by the Planning Service at the end of January.
Thomas Bell from Clyde Shanks said his clients were pleased that planning approval had been granted for the facility and that work should begin on site within the next few months.
“We are delighted to secure full planning permission for this state-of-the-art medical treatment facility outside of Hillsborough,” said Mr Bell.
“The prompt determination is testament to pre-application consultation with the local council, frontloading the application with robust supporting documentation and diligent consideration by Lisburn and Castlereagh City Council making for a prompt planning determination period.
“We understand that now permission is in place, the development is likely to commence Summer 2016.”