The collision took place on the Moyarget Road, Ballycastle.
Detective Sergeant Neil Harrison from the PSNI’s Collision Investigation Unit said: “Police received a report shortly before 12.10pm of a collision involving a car and a lorry.
"Officers, along with colleagues from other emergency services, attended. Sadly, a man, aged 62, passed away at the scene.
"A woman aged in her 70s has been taken to hospital for treatment for her injuries.
"The Moyarget Road currently remains closed to motorists at this time and is likely to remain so for a considerable period of time.
"Please avoid the area where possible and seek an alternative route for your journey.
"We are appealing to anyone who may have witnessed the collision, or have any dash cam footage, or information which could assist us with our investigation, to contact the Collision Investigation Unit 101, and quote reference number 765 of 19/05/23.”