The closure is operating from the Burn Road to the Ballymena Road.
A Department for Infrastructure (DfI) spokesperson said: “The road closure is required for the resurfacing of the carriageway.
“A diversion is to operate and delays over 15 minutes are expected.
“An alternative route is via Burn Road - Station Road - Ballymena Road (vice versa).”
The work, which is being carried out by DfI Roads contractors, is due to be completed by 6pm on Friday, September 16.