A lane closure, commencing at 7pm, will operate from the junction of Glenabbey Crescent to the Abbeyglen junction.
A Department for Infrastructure (DfI) spokesperson said: “The lane closure is required for Translink NI Railways bridge inspections and de-vegetation works.
“The closure is to operate overnight only. The work is being carried out by Translink NI Railways.”
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Road users are advised to expect estimated delays of over 15 minutes.
The work is due to be completed by 6am on Wednesday, August 3.